The neighborhood lies across the Mississippi River from downtown. The University of Minnesota forms its east boundary, and the west border of the neighborhood is the East Hennepin/Central Avenue commercial area.
Marcy-Holmes neighborhood, on the east bank of the Mississippi River, is named for William L. Marcy, an American statesman and secretary of state born in 1786 and Oliver Wendell Holmes, an American poet, essayist and novelist born in 1819. (Source: City of Minneapolis Neighborhood Profiles)
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